Vildagliptin 50 mg + Metformin 500 mg is a combination medication used to treat type 2 diabetes mellitus. Here are its uses: *Primary Uses* 1. *Type 2 Diabetes Mellitus*: This combination medication helps improve glycemic control (blood sugar control) in adults with type 2 diabetes. 2. *Insulin Resistance*: Vildagliptin and metformin work together to reduce insulin resistance, making it easier for glucose to enter cells. *Mechanism of Action* 1. *Vildagliptin*: Increases the levels of incretin hormones (GLP-1 and GIP), which stimulate insulin release and decrease glucagon levels. 2. *Metformin*: Decreases glucose production in the liver, increases insulin sensitivity, and enhances glucose uptake in muscles. *Benefits* 1. *Improved Glycemic Control*: Reduces HbA1c levels (average blood sugar levels over 3 months). 2. *Weight Management*: May help with weight loss or maintenance. 3. *Cardiovascular Benefits*: May reduce the risk of cardiovascular events, such as heart attacks and strokes. *Important Considerations* 1. *Prescription-only medication*: Available only by prescription from a healthcare provider. 2. *Dosage and administration*: Typically taken twice daily, with or without food. 3. *Side effects and interactions*: May cause side effects like headache, dizziness, and gastrointestinal issues. Interacts with other medications, such as beta-blockers and ACE inhibitors. *Contraindications* 1. *Hypersensitivity*: To vildagliptin, metformin, or any excipients. 2. *Severe renal impairment*: Creatinine clearance < 30 mL/min. 3. *Severe hepatic impairment*: Child-Pugh score ≥ 9. 4. *Lactic acidosis*: History of lactic acidosis or risk factors (e.g., kidney disease, liver disease). 5. *Pregnancy and breastfeeding*: Use with caution, as safety data are limited. Consult your healthcare provider for personalized guidance on using Vildagliptin 50 mg + Metformin 500 mg.